Targacept was a biotech company that spun off from RJ Reynolds [1] with the goal of making drugs related to nicotine that would help with schizophrenia and other psychiatric/neurological disorders. They tried really hard, and it didn't work [2].

[1] http://www.prnewswire.com/news-releases/rj-reynolds-tobacco-...

[2] http://www.journalnow.com/opinion/editorials/editorial-targa...